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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

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Related Experiment Video

Updated: Jun 16, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Maternal coagulation disorders and postpartum hemorrhage.

Robert M Silver1, Heather Major

  • 1Department of Obstetrics and Gynecology, University of Utah Medical Center, Salt Lake City, Utah, USA.

Clinical Obstetrics and Gynecology
|February 10, 2010
PubMed
Summary

Coagulation disorders are rare causes of postpartum hemorrhage but warrant suspicion in patients with a history of bleeding issues or menorrhagia. Early diagnosis is crucial for effective obstetric hemorrhage management.

Related Experiment Videos

Last Updated: Jun 16, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Area of Science:

  • Obstetrics and Gynecology
  • Hematology

Background:

  • Postpartum hemorrhage (PPH) is a leading cause of maternal mortality.
  • While uterine atony is the most common cause of PPH, coagulation disorders can also contribute.
  • Identifying the specific cause of PPH is critical for timely and effective management.

Purpose of the Study:

  • To highlight the importance of considering coagulation disorders in the differential diagnosis of postpartum hemorrhage.
  • To outline clinical clues suggestive of underlying coagulation defects in obstetric patients.
  • To emphasize the need for a high index of suspicion in diagnosing these rare but significant causes of PPH.

Main Methods:

  • Review of clinical literature and case studies related to postpartum hemorrhage and coagulation disorders.
  • Analysis of diagnostic criteria and clinical presentations associated with coagulopathies in obstetric patients.
  • Discussion of risk factors and historical indicators for coagulation abnormalities.

Main Results:

  • Coagulation disorders are an uncommon, but significant, cause of postpartum hemorrhage when considered as a sole etiology.
  • Family history of bleeding abnormalities and a personal history of menorrhagia are key indicators for suspecting a coagulation defect.
  • Specific clinical circumstances during or after delivery may also suggest an underlying coagulopathy.

Conclusions:

  • A high index of suspicion is essential for diagnosing coagulation disorders in patients experiencing postpartum hemorrhage.
  • Failure to consider coagulopathies can lead to delayed diagnosis and suboptimal management of obstetric hemorrhage.
  • Integrating family and personal bleeding history is vital in the comprehensive evaluation of PPH.