Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Respiratory modulation of neurophysiology and symptoms in athletes with sports-related concussion: a randomized crossover trial.

Frontiers in neuroscience·2026
Same author

Klotho suppresses cyst growth in ADPKD through the regulation of ferroptosis and reversing DNA methylation.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Regulation of trophoblast fusion dysfunction in preeclampsia by the NCK1/EIF3D/PPARG axis.

Biological research·2026
Same author

Towards mRNA therapeutics 2.0.

Nature reviews. Drug discovery·2026
Same author

Network pharmacology-based identification of cardamomin as a ferroptosis inhibitor in ischemic stroke via SP1/ALOX5 axis.

Pathology, research and practice·2026
Same author

SGIV envelope protein VP088 facilitated virus replication via interacting with other viral proteins and promoting p62-dependent autophagic degradation of TBK1.

Journal of virology·2025
Same journal

Why microglial repair programs fade.

Cell research·2026
Same journal

Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2.

Cell research·2026
Same journal

One drug, five targets.

Cell research·2026
Same journal

Smooth emotional response: amygdalar neurovascular coupling drives stress encoding.

Cell research·2026
Same journal

Liquid surrogates of spatial tumor ecosystems.

Cell research·2026
Same journal

MitoCatch directs mitochondria delivery and prevents cell degeneration.

Cell research·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells
12:13

Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells

Published on: August 23, 2014

Targeted conditional gene knockout in human embryonic stem cells

Lei Bu, Xiaolin Gao, Xin Jiang

    Cell Research
    |February 10, 2010
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    CRISPR-Cas9 Mediated Gene Deletion in Human Pluripotent Stem Cells Cultured Under Feeder-Free Conditions
    04:21

    CRISPR-Cas9 Mediated Gene Deletion in Human Pluripotent Stem Cells Cultured Under Feeder-Free Conditions

    Published on: November 1, 2024

    CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models
    10:57

    CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models

    Published on: August 24, 2022

    Related Experiment Videos

    Last Updated: Jun 16, 2026

    Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells
    12:13

    Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells

    Published on: August 23, 2014

    CRISPR-Cas9 Mediated Gene Deletion in Human Pluripotent Stem Cells Cultured Under Feeder-Free Conditions
    04:21

    CRISPR-Cas9 Mediated Gene Deletion in Human Pluripotent Stem Cells Cultured Under Feeder-Free Conditions

    Published on: November 1, 2024

    CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models
    10:57

    CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models

    Published on: August 24, 2022