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[The effect of dental plaque in cyclosporin A-induced gingival overgrowth]
Li-li Li1, Yuan-zheng Yin, Zhong-kai Wu
1Department of Periodontic, College of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. trili 2006@163.com
Purpose:
To evaluate the role of dental plaque in cyclosporin A(CsA)-induced gingival overgrowth.
Methods:
After extraction of half of the maxillary molars, twenty male Sprague-Dawley rats were assigned to a CsA-injection group (10mg/k x d) or a control group. Ten rats per group were sacrificed at week 4. The gingival width was measured under a stereomicroscope. Gingival specimens were taken, and the linear measurements were made with the help of software Image Pro-plus 6.0. The data was analyzed with SAS 6.12 software package.
Results:
The gingival width of the CsA group was significantly greater than the control group in both macroscopic analysis and histomorphometrical analysis (P<0.05).
Conclusions:
Dental plaque seems not to be a essential but to be a co-factor for the CsA-induced gingival overgrowth.
