Biomaterials/tissue interactions: possible solutions to overcome foreign body response.

Area of Science:

• Biomaterials Science
• Pharmaceutical Sciences
• Biomedical Engineering

Background:

• Implantable devices, especially drug/device combinations, are advancing.
• Host response to biomaterials compromises clinical application and device longevity.
• Understanding biomaterial-tissue interactions is crucial for device success.

Purpose of the Study:

• To review key issues in biomaterial/tissue interactions, including foreign body response and biocompatibility.
• To present strategies for overcoming in vivo instability of implantable devices.
• To summarize methods for mitigating host response, particularly for glucose biosensors.

Main Methods:

• Literature review focusing on biomaterial/tissue interactions.
• Analysis of biocompatibility assessment methodologies.
• Compilation of strategies to enhance in vivo device performance.

Main Results:

• Foreign body response and biocompatibility are critical factors affecting implantable devices.
• Strategies include biocompatible coatings, anti-inflammatory drugs, and angiogenic drugs.
• Specific approaches to manage host response for glucose biosensors are discussed.

Conclusions:

• Effective management of host response is essential for the clinical success of implantable devices.
• Biocompatible coatings and pharmaceutical interventions can improve device durability.
• Further research into mitigating foreign body responses will enhance future biomaterial applications.