Related Experiment Video
Updated: Jun 16, 2026

Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease
Published on: May 10, 2024
Vitamin A deficiency and wheezing
Zheng-Xiu Luo1, En-Mei Liu, Jian Luo
1Department of Respiratory Medicine, Children's Hospital, Chongqing Medical University, Chongqing, China. luozhengxiu816@163.com
Insights
Infant wheezing is linked to vitamin A deficiency. Lower vitamin A levels correlate with more persistent and severe wheezing episodes in infants, suggesting a significant relationship.
Area of Science:
- Pediatric Pulmonology
- Nutritional Science
- Clinical Research
Background:
- Vitamin A deficiency can heighten respiratory tract sensitivity, increasing infection risk and leading to wheezing.
- Infant wheezing is a common respiratory issue with potential links to nutritional status.
Purpose of the Study:
- To investigate the association between vitamin A deficiency and the occurrence of wheezing in infants.
- To explore the relationship between serum vitamin A levels and the severity and course of infant wheezing.
Main Methods:
- Collected venous blood samples from 331 hospitalized infants diagnosed with wheezing.
- Measured serum vitamin A concentration to assess deficiency levels.
- Analyzed the correlation between vitamin A status and wheezing characteristics.
Main Results:
- A higher prevalence of moderate and severe vitamin A deficiency was observed in infants with persistent wheezing compared to acute wheezing (P<0.01).
- Severe vitamin A deficiency was significantly more common in infants with severe wheezing than in those with mild or moderate wheezing (P<0.01).
- The degree of vitamin A deficiency correlated with both the duration and intensity of wheezing episodes.
Conclusions:
- Serum vitamin A deficiency is prevalent in infants experiencing wheezing.
- The severity of vitamin A deficiency appears to be associated with the course and severity of wheezing in infants.
Background:
Vitamin A deficiency may increase the responsiveness of the respiratory tract and increase the risk of respiratory tract infection, resulting in airway obstruction and wheezing. This study aimed to investigate the relation between vitamin A deficiency and infant wheezing.
Methods:
Three ml venous blood samples were collected from 331 hospitalized children who suffered from wheezing to determine the serum vitamin A concentration and the relationship between vitamin A and some causative factors of wheezing.
Results:
The severity of vitamin A deficiency was related to the course of wheezing. In the persistent wheezing group, 14 patients (34.1%) were diagnosed as having severe vitamin A deficiency and 16 patients (39%) having moderate vitamin A deficiency; among the acute wheezing group, 18 patients (16.4%) were diagnosed as having severe vitamin A deficiency and 32 patients (29%) having moderate vitamin A deficiency. Comparison of the two groups revealed that there was a significantly higher rate of moderate and severe vitamin A deficiency in the persistent wheezing group than in the acute wheezing group (P<0.01). The severity of vitamin A deficiency was related to the infants' wheezing severity. Severe vitamin A deficiency was found in 24 patients (47%) in the severe wheezing group and 8 (8%) in the mild and moderate wheezing groups. The rate of severe vitamin A deficiency was significantly higher in patients with severe wheezing than in those with mild and moderate wheezing (P<0.01).
Conclusions:
Serum vitamin A deficiency could be commonly found in infants with wheezing. The severity of vitamin A deficiency might be related to the course of wheezing and the infants' wheezing severity.
Related Concept Videos
Asthma I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma III: Clinical Manifestations
Asthma-I: Introduction
Vitamins
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
