Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
Regulation of Sodium and Potassium01:26

Regulation of Sodium and Potassium

The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily in...
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
Reabsorption and Secretion in the PCT01:28

Reabsorption and Secretion in the PCT

The Proximal Convoluted Tubule, or PCT, plays a pivotal role in the body's filtration system. They are primarily responsible for reabsorbing solutes and water from the filtered fluid produced by the glomeruli. Most of the filtered water, ions, and organic solutes such as glucose and amino acids are reabsorbed by the PCT.
Transport mechanisms involving sodium ions (Na+) contribute significantly to solute reabsorption. These mechanisms include symport and antiport processes.
A key example is the...
Reabsorption and Secretion in the Loop of Henle01:17

Reabsorption and Secretion in the Loop of Henle

The thick ascending limb of the nephron loop has Na+–K+–2Cl− symporters in the apical membranes of its cells. These symporters simultaneously reclaim one sodium ion, one potassium ion, and two chloride ions from the tubular fluid. Sodium ions are actively transported into the interstitial fluid at the base and sides of the cell, diffusing into the vasa recta. Chloride ions move through leakage channels in the basolateral membrane into the interstitial fluid and then into the vasa recta.
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CFTR knock-out mice exhibit impaired renal compensation to dietary NaCl depletion.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Elexacaftor/tezacaftor/ivacaftor corrects salt-wasting in cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2025
Same author

Renal Ghrelin-Family GPR39 Receptor and Urinary Concentrating Ability.

Journal of the American Society of Nephrology : JASN·2025
Same author

A Urine pH-Ammonium Acid/Base Score and CKD Progression.

Journal of the American Society of Nephrology : JASN·2024
Same author

Revisiting voltage-coupled H<sup>+</sup> secretion in the collecting duct.

American journal of physiology. Renal physiology·2024
Same author

The challenged urine bicarbonate excretion test in cystic fibrosis: A comprehensive analysis of urine acid/base parameters.

Acta physiologica (Oxford, England)·2024
Same journal

Expression of protein kinase A catalytic subunits in healthy and diseased mouse kidneys.

Pflugers Archiv : European journal of physiology·2026
Same journal

Localization of O₂‑sensing ADO‑RGS pathway components in mouse and human kidneys under normoxia, hypoxia and renal fibrosis.

Pflugers Archiv : European journal of physiology·2026
Same journal

Cholesterol-depleting dextrin depolarizes sarcolemma: the contribution of sodium / calcium channels and membrane integrity.

Pflugers Archiv : European journal of physiology·2026
Same journal

Inhibition of (interstitial) P2Y<sub>6</sub> receptors attenuates fibrosis progression.

Pflugers Archiv : European journal of physiology·2026
Same journal

Renal NHE3 is required to limit hypokalemia and metabolic acidosis during dietary potassium deficiency.

Pflugers Archiv : European journal of physiology·2026
Same journal

Xenin-25 improves indomethacin-induced acute gastric injury in rats.

Pflugers Archiv : European journal of physiology·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain
11:20

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain

Published on: May 7, 2018

Colonic potassium handling.

Mads V Sorensen1, Joana E Matos, Helle A Praetorius

  • 1Department of Physiology and Biophysics, Aarhus University, Ole Worms Alle 1160, 8000 Aarhus C, Denmark.

Pflugers Archiv : European Journal of Physiology
|February 10, 2010
PubMed
Summary
This summary is machine-generated.

Maintaining stable plasma potassium (K+) levels is vital. This review highlights the apical calcium (Ca2+) and cAMP-activated BK channel (KCa1.1) as the primary K+ secretory channel in the distal colon.

More Related Videos

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Isolating and Using Sections of Bovine Mesenteric Artery and Vein as a Bioassay to Test for Vasoactivity in the Small Intestine
07:32

Isolating and Using Sections of Bovine Mesenteric Artery and Vein as a Bioassay to Test for Vasoactivity in the Small Intestine

Published on: October 7, 2014

Related Experiment Videos

Last Updated: Jun 16, 2026

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain
11:20

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain

Published on: May 7, 2018

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Isolating and Using Sections of Bovine Mesenteric Artery and Vein as a Bioassay to Test for Vasoactivity in the Small Intestine
07:32

Isolating and Using Sections of Bovine Mesenteric Artery and Vein as a Bioassay to Test for Vasoactivity in the Small Intestine

Published on: October 7, 2014

Area of Science:

  • Physiology
  • Nephrology
  • Gastroenterology

Background:

  • Homeostatic control of plasma potassium (K+) is essential for physiological function.
  • The kidney's distal tubules are the primary site for K+ excretion, with the intestine handling about 10%.
  • Colonic K+ secretion increases in chronic renal insufficiency and can be life-threatening during severe diarrhea.

Purpose of the Study:

  • To provide an update on the molecular mechanisms and regulation of mammalian colonic K+ absorption and secretion.
  • To focus on recent findings identifying the K+ secretory ion channel in distal colonic enterocytes.
  • To examine the role of the apical Ca2+ and cAMP-activated BK channel (KCa1.1) in colonic K+ secretion.

Main Methods:

  • Literature review of molecular mechanisms and regulation of colonic K+ transport.
  • Analysis of recent research identifying specific ion channels involved in K+ secretion.
  • Focus on the function of the BK channel (KCa1.1) in distal colonic enterocytes.

Main Results:

  • The apical Ca2+ and cAMP-activated BK channel (KCa1.1) is identified as the principal secretory K+ channel in the distal colon.
  • Understanding this channel's regulation is crucial for managing K+ homeostasis.
  • Enhanced colonic secretion plays a significant role in K+ balance, especially in renal insufficiency and diarrheal diseases.

Conclusions:

  • The BK channel (KCa1.1) is the key player in distal colonic K+ secretion.
  • Further research into BK channel regulation is critical for understanding K+ homeostasis and related diseases.
  • This review emphasizes the importance of colonic K+ handling in overall physiological balance.