Two new triterpene glycosides from Centella asiatica
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Published on: February 2, 2024
Chidananda Swamy Rumalla1, Zulfiqar Ali, Aruna D Weerasooriya
1National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.
Abstract:
Phytochemical investigation of the leaves of Centella asiatica resulted in the isolation and characterization of eight triterpenes and/or saponins [which were characterized as 23- O-acetylmadecassoside (1), asiatic acid (2), madecassic acid (3), asiaticoside C (4), asiaticoside F (5), asiaticoside (6), madecassoside (7), and 23- O-acetylasiaticoside B (8)] together with sitosterol 3-O-beta-glucoside ( 9), stigmasterol 3- O- beta-glucoside (10), and querectin-3- O-beta-D-glucuronide (11). A new ursane-derived saponin (23- O-acetylmadecassoside) and a new oleanane-derived saponin (23- O-acetylasiaticoside B) were found as well. Structure elucidation was done by using spectroscopic techniques (HR-ESI-MS, 1D and 2D NMR), chemical methods, and comparative literature studies.
