[Progress in cardiovascular surgery: new analytical, experimental, and technological approaches]

Area of Science:

• Fluid dynamics
• Cardiovascular science
• Biomedical engineering

Context:

• Blood flow in the heart and major vessels exhibits complex, self-organizing eddy flow patterns.
• Kiknadze-Krasnov's non-stationary hydrodynamic equations provide a framework for understanding this flow.
• Current treatments for cardiovascular diseases require advanced simulation and device design.

Purpose:

• To apply non-stationary hydrodynamic equations for simulating blood circulation.
• To evaluate the efficacy of surgical treatments for cardiovascular diseases.
• To design novel implantable cardiovascular devices that support physiological blood flow.

Summary:

• The study details the application of Kiknadze-Krasnov's equations to model blood circulation.
• A new all-flow three-leaflet CorBit artificial heart valve made of pyrolytic carbon was developed.
• The CorBit valve minimizes regurgitation and pressure gradients, normalizing hemodynamics post-implantation.
• Development of BioLab bioprostheses (stented/stentless) from biological tissues for treating complex cardiopathology is also discussed.

Impact:

• Enables accurate simulation of blood circulation in normal and pathological states.
• Facilitates quantitative assessment of surgical treatment effectiveness for cardiovascular diseases.
• Supports the design of advanced implantable devices for cardiovascular surgery.
• Offers improved artificial heart valves (CorBit) and bioprostheses (BioLab) for better patient outcomes.