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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

[Cerebral circulation in chronic hypertensive encephalopathy]

L A Geraskina, T N Sharypova, V V Mashin

    Klinicheskaia Meditsina
    |February 11, 2010
    PubMed

    Insights

    Hypertensive encephalopathy (HE) impairs cerebral blood flow, particularly in deeper brain areas. This study shows reduced blood flow in major cerebral arteries and altered cortical blood flow, correlating with HE severity.

    Area of Science:

    • Neurology
    • Radiology
    • Vascular Medicine

    Background:

    • Hypertensive encephalopathy (HE) is a severe neurological condition.
    • Understanding cerebral blood flow (CBF) dynamics is crucial for managing HE.
    • Previous studies have not fully elucidated the pattern of CBF alterations in different HE stages.

    Purpose of the Study:

    • To investigate cerebral blood supply in patients with stage III hypertensive encephalopathy.
    • To correlate CBF changes with the severity of HE.
    • To identify indicators of hypoperfusion in HE.

    Main Methods:

    • Studied 123 patients with stage III hypertensive encephalopathy.
    • Measured blood flow in common carotid (CCA), vertebral (VA), and medial cerebral arteries (MCA) using duplex scanning.
    • Assessed cortical CBF using single-photon emission CT (SPECT) with 99mTc-ceretec.

    Main Results:

    • Normal blood flow was observed in CCA and VA across all HE stages.
    • Blood flow in MCA decreased in patients with HE stages II-III.
    • Cortical CBF in frontal and parietal regions was higher in HE II-III compared to HE I.
    • Leukoaraiosis was identified as an indicator of hypoperfusion.

    Conclusions:

    • Hypertensive encephalopathy is associated with impaired subcortical perfusion.
    • A discrepancy between cortical and subcortical blood supply correlates with HE severity.
    • Leukoaraiosis serves as a marker for hypoperfusion in HE.

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