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Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
Published on: November 28, 2025
[First open heart surgery in hypothermia in Croatia performed in 1957]
Miroslav Hromadko1, Stella Fatović-Ferencić
1Akademija medicinskih znanosti Hrvatske.
Lijecnicki Vjesnik
|February 11, 2010
Abstract:
In Zagreb, at the Surgical Department of University Hospital "Dr Ozren Novosel", today "Merkur" the first operation in hypothermia was performed on October 25th, 1957, on the patient with pulmonary valve stenosis. It allowed total circulatory interruption to do the operation in the open heart successfully, and this was the first such operation not only in Croatia but in the broader context of former Yugoslavia.

