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Related Experiment Video

Updated: Jun 16, 2026

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
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Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

Lung perfusion imaging with monosized biodegradable microspheres.

Urs O Häfeli1, Katayoun Saatchi, Philipp Elischer

  • 1Faculty of Pharmaceutical Sciences and Department of Mechanical Engineering, The University of British Columbia, Vancouver, British Columbia, Canada. uhafeli@interchange.ubc.ca

Biomacromolecules
|February 11, 2010
PubMed
Summary
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Monosized biodegradable microspheres can replace technetium-99m-macroaggregated albumin for lung perfusion imaging. These novel radioactive microspheres demonstrate effective lung uptake, offering potential for improved medical diagnostics and therapeutics.

Area of Science:

  • Biomedical Engineering
  • Nuclear Medicine
  • Materials Science

Background:

  • Lung perfusion imaging is crucial in nuclear medicine.
  • Technetium-99m-macroaggregated albumin (99mTc-MAA) is the current standard but has limitations.
  • Particles injected intravenously lodge in the first encountered capillary bed, enabling imaging.

Purpose of the Study:

  • To evaluate monosized biodegradable microspheres as a potential replacement for 99mTc-MAA.
  • To assess the efficacy of these microspheres for lung perfusion imaging.

Main Methods:

  • Biodegradable poly(L-lactide) microspheres with chelating groups were synthesized using microfluidics.
  • Microspheres were radiolabeled with 99mTc.
  • Lung perfusion imaging was performed in mice after intravenous injection.

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Last Updated: Jun 16, 2026

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
09:00

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

Main Results:

  • Highly uniform microspheres (9.0 ± 0.4 µm) were produced.
  • Significant lung uptake of 79.6 ± 3.8% was observed 15 minutes post-injection.
  • The microspheres demonstrated suitability as lung perfusion imaging agents.

Conclusions:

  • Monosized biodegradable radioactive microspheres are effective agents for lung perfusion imaging.
  • These microspheres show promise as an alternative to 99mTc-MAA.
  • Potential exists for diverse medical applications with varying microsphere sizes.