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Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Methods to Assess Microbial Communities01:19

Methods to Assess Microbial Communities

Microbial communities, comprising bacteria, archaea, and eukaryotic microorganisms, inhabit diverse ecosystems and play crucial roles in environmental and biological processes. Their diversity is defined by three main parameters: species richness (the number of distinct species), species abundance (the relative quantity of each species), and species evenness (how uniformly individual species are distributed in various locations). These factors together shape the structure and ecological balance...

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Related Experiment Video

Updated: Jun 16, 2026

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

Metabolomics: towards understanding host-microbe interactions.

Jun Han1, L Caetano M Antunes, B Brett Finlay

  • 1University of Victoria - Genome BC Proteomics Centre, 3101-4464 Markham Street, Victoria, BC, V8Z 7X8, Canada. hanjun@proteincentre.com

Future Microbiology
|February 11, 2010
PubMed
Summary
This summary is machine-generated.

Metabolomics uses advanced techniques to analyze small molecules in biological samples. This helps understand how microbes and hosts interact, offering insights into diseases caused by microbial imbalances.

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High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
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Last Updated: Jun 16, 2026

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Area of Science:

  • Biochemistry and Systems Biology
  • Microbiome Research
  • Metabolomics

Background:

  • Metabolomics analyzes hundreds to thousands of small molecules in biological samples.
  • It characterizes metabolic phenotypes (metabotypes) in hosts, particularly the gut microbiome.
  • Host-microbe interactions are crucial for understanding health and disease.

Purpose of the Study:

  • To characterize host metabolic phenotypes using metabolomics.
  • To correlate host metabotypes with microbial profiles.
  • To understand host-microbe relationships and their role in disease.

Main Methods:

  • High-resolution nuclear magnetic resonance spectroscopy
  • Mass spectrometry
  • Chemoinformatics and bioinformatics tools
  • Culture-independent molecular techniques for microbial profiling

Main Results:

  • Comprehensive characterization of host metabolic phenotypes.
  • Correlation of metabotypes with microbial communities.
  • Deciphering host-microbe relationships.

Conclusions:

  • Integrated metabolomics and microbiome analysis advances systems biology understanding of host-microbe interactions.
  • This approach promises to elucidate etiologies of human disorders linked to microbial dysbiosis.
  • It offers potential for understanding enteric infections and other microbiome-related diseases.