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Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
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Microbe-plant interactions represent a dynamic spectrum of associations shaped by intricate chemical signaling. These interactions can be neutral, beneficial, or detrimental, and profoundly influence plant physiology, growth, and ecosystem function. The plant microbiome, comprising bacteria, fungi, archaea, protists, and viruses, plays a pivotal role in mediating these effects through surface colonization, internal colonization, or systemic symbiosis.Mutualistic associations, particularly with...
Microbial Interactions: Cooperation01:26

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Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
Applications of Molecular Taxonomy01:20

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Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...

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Updated: Jun 16, 2026

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics.

Daniel E Sturdevant1, Kimmo Virtaneva, Craig Martens

  • 1Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA. dsturdevant@niaid.nih.gov

Future Microbiology
|February 11, 2010
PubMed
Summary

Microarray and comparative genomics reveal host-pathogen interactions and pathogen evolution. These technologies advance understanding of infectious diseases and aid in combating them.

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A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
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A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae

Published on: April 25, 2015

Area of Science:

  • Genomics
  • Infectious Disease Research
  • Molecular Biology

Background:

  • Host-pathogen interactions are central to infectious disease processes.
  • Understanding these interactions requires advanced analytical tools.

Purpose of the Study:

  • To explore the utility of microarray and comparative genomic technologies in analyzing host-pathogen interactions.
  • To elucidate pathogen intracellular lifecycles and host responses during infection.

Main Methods:

  • Transcriptome analysis at various time points during infection.
  • In vivo host-pathogen transcriptome analysis over time.
  • Comparative genomics via microarray-based comparative whole-genome resequencing or de novo whole-genome sequencing.

Main Results:

  • Transcriptome analysis provides insights into pathogen intracellular lifecycles.
  • In vivo analysis characterizes dynamic host and pathogen responses.
  • Comparative genomics identifies genetic factors in pathogen evolution and pathogenesis.

Conclusions:

  • Microarray and comparative genomics enhance understanding of host-pathogen dynamics.
  • These technologies are crucial for studying pathogen evolution and combating infectious diseases.