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Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
Published on: June 11, 2017
The relationship between endothelial damage and aortic augmentation index.
Omer Gedikli1, Abdulkadir Kiris, Hulya Yilmaz
1Karadeniz Technical University, Departmant of Cardiology, Trabzon, Turkey. omergedikli@ yahoo.com
Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|February 11, 2010
Summary
Increased levels of von Willebrand factor (vWF), an endothelial damage marker, are linked to heightened wave reflections in hypertension. Soluble thrombomodulin (sTM) showed no association with wave reflections in this study.
Area of Science:
- Cardiovascular Physiology
- Vascular Biology
- Hypertension Research
Background:
- Augmentation index (AIx) reflects wave reflections, influenced by endothelial function and vascular tone.
- While local endothelial factors and AIx are known, the link between endothelial damage markers and AIx requires further investigation.
Purpose of the Study:
- To investigate the association between endothelial damage markers, specifically von Willebrand factor (vWF) and soluble thrombomodulin (sTM), and wave reflections (AIx@75).
Main Methods:
- Studied 46 never-treated hypertensive patients and 40 normotensive controls.
- Measured vWF and sTM levels.
- Assessed aortic AIx using applanation tonometry, calculating heart rate-corrected AIx (AIx@75).
Main Results:
- Hypertensive patients exhibited higher endothelial damage markers and AIx@75 compared to controls.
- vWF levels were significantly higher in hypertensive patients.
- Multivariate analysis revealed vWF as an independent determinant of AIx@75 (beta = 0.24, p = 0.01), while sTM was not associated with AIx@75.
Conclusions:
- Elevated vWF levels significantly contribute to increased wave reflections in hypertensive individuals.
- vWF may serve as a marker for endothelial damage contributing to arterial stiffness in hypertension.
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