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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: Jun 16, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

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The intestine and rheumatism.

B Olhagen1

  • 1Dept. of Rheumatology, Karolinska Sjukhuset, Stockholm, Sweden.

Scandinavian Journal of Rheumatology
|February 11, 2010
PubMed
Summary

Intestinal infections, like those caused by Clostridium perfringens, can trigger rheumatic reactions. Research suggests a link between abnormal gut bacteria and immune responses in rheumatoid arthritis patients.

Area of Science:

  • Gastroenterology
  • Rheumatology
  • Microbiology

Background:

  • Intestinal infections are known to cause rheumatic reactions.
  • Specific microbes like Clostridium perfringens and Yersinia enterocolitica are implicated in enterocolitis.
  • Abnormal intestinal flora has been observed in patients with chronic arthritis.

Purpose of the Study:

  • To investigate the role of intestinal microbes in rheumatic reactions following infections.
  • To explore the association between Clostridium perfringens and rheumatoid disease.

Main Methods:

  • Review of recent observations linking specific microbes to enterocolitis.
  • Analysis of findings regarding abnormal intestinal flora in arthritis patients.
  • Examination of antibodies to Clostridium perfringens alphatoxin.

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

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Last Updated: Jun 16, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Main Results:

  • Clostridium perfringens and Yersinia enterocolitica are potential culprits in certain enterocolitis cases.
  • Abnormal intestinal flora, particularly C. perfringens, is noted in chronic arthritis patients.
  • Presence of antibodies to C. perfringens alphatoxin suggests an immune response.

Conclusions:

  • Intestinal infections can indeed elicit rheumatic reactions.
  • Clostridium perfringens may play a role in the immunopathogenesis of rheumatoid disease.