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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

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Sjögren's Syndrome Associated with Vitamin B(12) Deficiency.

O Wegelius¹, F Fyhrquist, P L Adner

¹Fourth Department of Medicine, University Central Hospital, Helsinki, Finland.

Scandinavian Journal of Rheumatology

|February 11, 2010

Summary

Sjögren's syndrome can be linked to vitamin B12 deficiency anemia. Autoimmune factors may play a role in the development of both conditions, suggesting a shared underlying pathogenesis.

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Area of Science:

Immunology
Gastroenterology
Hematology

Background:

Sjögren's syndrome is an autoimmune disorder primarily affecting exocrine glands.
Macrocytic anemia due to vitamin B12 deficiency is a known hematological condition.
Autoimmune conditions often have overlapping etiologies.

Purpose of the Study:

To describe patients with concurrent Sjögren's syndrome and vitamin B12 deficiency anemia.
To investigate the role of autoantibodies in the pathogenesis of this association.
To explore potential etiological factors linking these two conditions.

Main Methods:

Clinical case descriptions of three patients.
Serological testing for antibodies to parietal cells, intrinsic factor, and salivary protein.
Assessment for achylia and malabsorption.

Main Results:

All three patients presented with Sjögren's syndrome and macrocytic anemia.
Positive autoantibody results (parietal cell, intrinsic factor, salivary protein) were observed in varying combinations.
One patient exhibited anti-parietal cell antibodies and histamine-refractory achylia.

Conclusions:

The co-occurrence of Sjögren's syndrome and vitamin B12 deficiency anemia suggests a potential autoimmune link.
Possible causes include autoimmune gastritis (Addisonian pernicious anemia) or vitamin B12 malabsorption due to intrinsic factor antibodies or intestinal changes.
Shared autoimmune pathogenesis may underlie the concurrence of these conditions.