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Sjögren's Syndrome Associated with Vitamin B(12) Deficiency
O Wegelius1, F Fyhrquist, P L Adner
1Fourth Department of Medicine, University Central Hospital, Helsinki, Finland.
Abstract:
Three patients showing Sjögren's syndrome in association with macrocytic anemia due to vitamin B(12) deficiency are described. Antibodies to parietal cells, intrinsic factor and salivary protein were investigated; positive test results were obtained in different combinations. Addisonian pernicious anemia as well as vitamin B(12)-malabsorption because of anti-intrinsic factor antibodies in gastric juice and/or malabsorption due to changes in the intestinal wall induced by Sjögren's syndrome are possible etiological factors. A case of Sjögren's syndrome associated with positive anti-parietal cell antibodies and histaminerefractory achylia is also reported. The concurrence of these two diseases known to be associated with autoimmune responses suggests the possibility of similar pathogenesis.
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