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Synovial Fluid Analysis to Identify Osteoarthritis
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Changes in the synovial fluid caused by osmic Acid.
G Lörincz1, H A Isomäki, J Martio
1Rheumatism Foundation Hospital, Heinola, Finland.
Scandinavian Journal of Rheumatology
|February 11, 2010
Summary
Osmic acid affects synovial fluid in rheumatic patients, initially causing leucopenia then leucocytosis. This suggests a new hypothesis for osmic acid
Area of Science:
- Rheumatology
- Biochemistry
- Medical Science
Background:
- Knee joint hydrops is a common condition in rheumatic diseases.
- Synovial fluid analysis is crucial for understanding joint inflammation.
Purpose of the Study:
- To investigate the effects of osmic acid on synovial fluid in patients with rheumatic knee joint hydrops.
- To analyze changes in synovial leucocyte counts and electrophoretic patterns.
Main Methods:
- Studied 27 rheumatic patients with knee joint hydrops.
- Monitored synovial leucocyte counts.
- Examined synovial fluid electrophoretic patterns after osmic acid injection.
Main Results:
- Osmic acid induced an initial leucopenia followed by leucocytosis in synovial fluid.
- A precipitate formation from hyaluronate was observed, potentially causing leucopenia.
- Electrophoretic patterns showed transient changes in protein electric charges.
Conclusions:
- Osmic acid's action on synovial fluid involves hyaluronate precipitation and protein charge alteration.
- A new hypothesis for osmic acid's mechanism of action is proposed.
- Synovial fluid electrophoretic patterns returned to normal within one week.
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