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Updated: Jun 16, 2026

Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Changes in the synovial fluid caused by osmic Acid
G Lörincz1, H A Isomäki, J Martio
1Rheumatism Foundation Hospital, Heinola, Finland.
Abstract:
27 rheumatic patients with knee joint hydrops were studied for the effect of osmic acid on the synovial fluid. Special interest was taken in synovial leucocyte counts and electrophoretic patterns. A leucopenia preceded the leucocytosis in the synovial samples; both were thought to be induced by osmium. A precipitate formation from hyaluronate was thought to account for the leucopenia and this suggests a new hypothesis of osmic acid action. In the electrophoretic patterns there was a change in the electric charges of proteins. One week after osmic acid injection the pattern was normal.
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