Dispersed cell cultures of rheumatoid synovial membrane

The morphology of cells released from synovial tissues involved by rheumatoid arthritis and grown in tissue culture has been described. Cultures were well established and differentiated by the third day. In growth medium enriched with heat-inactivated rheumatoid serum syncytial cell masses frequently formed. This change particularly, was very like the characteristic cytopathic effect of a number of viruses.