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Related Experiment Video

Updated: Jun 16, 2026

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
11:49

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

Published on: November 17, 2013

Hyperbaric oxygen therapy improves early posttransplant islet function.

Naoaki Sakata1, Nathaniel K Chan, Robert P Ostrowski

  • 1Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.

Pediatric Diabetes
|February 11, 2010
PubMed
Summary
This summary is machine-generated.

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Hyperbaric oxygen therapy (HBO) reduced hypoxia and improved blood vessel maturation after islet transplantation. This suggests HBO may enhance engraftment by promoting healthier vasculature in transplanted islets.

Area of Science:

  • Regenerative Medicine
  • Transplantation Biology
  • Vascular Biology

Background:

  • Intraportal islet transplantation is a potential treatment for type 1 diabetes.
  • Hypoxia and poor vascularization can limit islet graft survival and function.
  • Hyperbaric oxygen therapy (HBO) may improve oxygenation and promote angiogenesis.

Purpose of the Study:

  • To investigate the therapeutic potential of HBO in reducing hypoxia and improving angiogenesis in intraportal islet transplants.
  • To assess the impact of HBO on islet engraftment and vascularization.

Main Methods:

  • Diabetic mice received intraportal islet transplants and HBO treatment.
  • Dynamic contrast-enhanced MRI (DCE-MRI) assessed neovascularization.
  • Histological analysis examined hypoxia markers (HIF-1α, TUNEL) and angiogenic factors (VEGF, vWF).

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Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)
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Published on: March 14, 2019

Related Experiment Videos

Last Updated: Jun 16, 2026

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
11:49

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

Published on: November 17, 2013

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice
06:41

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice

Published on: May 10, 2021

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)
07:36

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

Published on: March 14, 2019

Main Results:

  • HBO significantly reduced HIF-1α, TUNEL, and VEGF expression at postoperative day 7.
  • DCE-MRI showed suppressed liver enhancement in HBO-treated mice at postoperative day 7, indicating more mature vasculature.
  • The number of new peri-islet vessels did not differ significantly between groups.

Conclusions:

  • HBO therapy decreased hypoxia following islet transplantation.
  • HBO appeared to enhance blood vessel maturation in the critical early period after transplantation.
  • These findings suggest HBO may improve islet graft outcomes by modulating the vascular environment.