Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fluid challenge and left ventricular myocardial performance index assessed by transthoracic echocardiography with tissue Doppler imaging in critically ill patients with regular rhythm.

Frontiers in medicine·2026

Same author

Personalized mechanical ventilation guided by lung ultrasound in patients with ARDS: a pilot phase of a randomized clinical trial.

Intensive care medicine experimental·2025

Same author

Effects of secular changes in tidal volume and respiratory rate on the mechanical power of ventilation: a retrospective single-center study of invasively ventilated patients.

Critical care science·2025

Same author

Neutrophil Extracellular Traps in the Prognosis of Sepsis: A Current Update.

Medicina (Kaunas, Lithuania)·2025

Same author

A Two-for-One Diagnosis: A Rare Case of Chronic Abdominal Pain Caused by Gastroptosis and Wilkie's Syndrome in a Young Woman.

Diagnostics (Basel, Switzerland)·2025

Same author

Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial.

Trials·2024

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Sepsis biomarkers: a review.

Charalampos Pierrakos¹, Jean-Louis Vincent

¹Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, route de Lennik 808, 1070 Brussels, Belgium. charalampos_p@hotmail.com

Critical Care (London, England)

|February 11, 2010

Summary

Numerous sepsis biomarkers exist, but none are sufficiently accurate for routine clinical use. Procalcitonin (PCT) and C-reactive protein (CRP) are common but have limited diagnostic and prognostic capabilities.

Area of Science:

Clinical Microbiology and Infectious Diseases
Biomarker Discovery and Validation

Background:

Biomarkers are crucial for sepsis management, aiding in diagnosis, treatment selection, and response assessment.
Effective sepsis biomarkers can improve patient outcomes and guide clinical decision-making.

Purpose of the Study:

To systematically review the literature on biomarkers evaluated for sepsis.
To assess the diagnostic and prognostic utility of various sepsis biomarkers in clinical practice.

Main Methods:

Conducted an electronic literature search of the PubMed database.
Utilized keywords 'sepsis' and 'biomarker' to identify relevant clinical and experimental studies.
Included studies evaluating any biomarker for sepsis.

More Related Videos

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Jun 16, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Main Results:

The search identified 3,370 references, encompassing 178 distinct biomarkers for sepsis.
Most evaluated biomarkers have been tested clinically, primarily for prognosis rather than diagnosis.
Procalcitonin (PCT) and C-reactive protein (CRP) are the most frequently utilized biomarkers.

Conclusions:

While many sepsis biomarkers exist, none currently meet the criteria for routine clinical application due to insufficient specificity and sensitivity.
Existing biomarkers like PCT and CRP show limitations in differentiating sepsis from other inflammatory conditions and predicting patient outcomes.
Further research is needed to identify and validate more accurate sepsis biomarkers for clinical practice.