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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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The case for personalized medicine.

Edward Abrahams1, Mike Silver

  • 1Personalized Medicine Coalition, Washington, DC 20005, USA. eabrahams@personalizedmedicinecoalition.org

Journal of Diabetes Science and Technology
|February 11, 2010
PubMed
Summary
This summary is machine-generated.

Personalized medicine uses patient-specific molecular markers for more precise disease prevention and treatment. This approach offers significant value but requires overcoming adoption barriers to maximize its potential in healthcare.

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Area of Science:

  • Biomedical research
  • Genomics
  • Pharmacology

Background:

  • Traditional medicine offers a one-size-fits-all approach to disease treatment.
  • Advancements in molecular biology and diagnostics have enabled a more precise understanding of individual disease susceptibility and treatment response.

Purpose of the Study:

  • To present real-world examples demonstrating the value of personalized medicine.
  • To advocate for the continued growth and adoption of personalized medicine.

Main Methods:

  • Review of real-world case studies and clinical data.
  • Analysis of the impact of personalized medicine on individuals, industry, and healthcare systems.

Main Results:

  • Personalized medicine, utilizing genetic variation and molecular markers, enhances treatment selection and disease prediction.
  • Demonstrated value in improved clinical care, reduced trial durations, and cost savings.

Conclusions:

  • Personalized medicine is delivering significant value across healthcare.
  • Addressing barriers to adoption and creating incentives are crucial for its future growth and importance.