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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

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Updated: Jun 16, 2026

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
15:18

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research

Published on: January 12, 2013

Noninvasive optical screening for diabetes.

Marwood N Ediger1, Byron P Olson, John D Maynard

  • 1VeraLight, Inc., Albuquerque, New Mexico87106, USA. woody.ediger@veralight.com

Journal of Diabetes Science and Technology
|February 11, 2010
PubMed
Summary
This summary is machine-generated.

Noninvasive skin fluorescence measurement shows promise for early diabetes detection. This method is more sensitive than traditional blood tests and offers immediate results without fasting or blood draws, aiding opportunistic screening.

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Published on: October 23, 2020

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Last Updated: Jun 16, 2026

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
15:18

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research

Published on: January 12, 2013

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Metabolic Disease Research

Background:

  • Advanced glycation end products (AGEs) are linked to diabetes complications.
  • Skin accumulation of AGEs serves as a biomarker for diabetes risk.
  • Fluorescent AGEs can be measured noninvasively using optical spectroscopy.

Purpose of the Study:

  • To evaluate noninvasive screening for diabetes using dermal fluorescence.
  • To compare the sensitivity of skin fluorescence with traditional diabetes screening methods.

Main Methods:

  • An 18-site study involved 2793 subjects meeting American Diabetes Association screening criteria.
  • Subjects underwent measurements using a specialized skin fluorimeter.
  • Traditional blood glucose and glycated hemoglobin tests were also performed for comparison.

Main Results:

  • Noninvasive dermal fluorescence measurement demonstrated higher sensitivity in detecting abnormal glucose tolerance compared to fasting plasma glucose.
  • Skin fluorescence was also more sensitive than glycated hemoglobin A1C in identifying glucose intolerance.

Conclusions:

  • Noninvasive dermal fluorescence measurement may effectively identify individuals at risk for diabetes and its complications.
  • The technology provides immediate results and does not require blood draws or patient fasting.
  • This noninvasive approach is suitable for opportunistic diabetes screening.