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Published on: August 13, 2019
Maxillary sinus floor elevation using a tissue engineered bone complex with BMP-2 gene modified bMSCs and a novel
X-Juan Sun1, L-Guo Xia, L Lee Chou
1Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. ms_sunxiaojuan@126.com
Archives of Oral Biology
|February 11, 2010
Summary
Gene-modified bone marrow stromal cells (bMSCs) enhanced new bone formation for maxillary sinus floor elevation in rabbits. The OsteoBone scaffold proved effective for gene-enhanced bone tissue engineering.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Maxillary sinus floor elevation is crucial for dental implantology.
- Tissue-engineered bone grafts offer potential solutions for bone regeneration.
Purpose of the Study:
- To evaluate the efficacy of gene-modified bone marrow stromal cells (bMSCs) with bone morphogenetic protein-2 (BMP-2) using a novel OsteoBone scaffold for maxillary sinus floor elevation in rabbits.
Main Methods:
- bMSCs were transduced with AdBMP-2 or AdEGFP (control) and combined with the OsteoBone scaffold.
- The engineered bone complex was used for maxillary sinus floor elevation in rabbits.
- Histologic and histomorphometric analyses were performed at 2 and 4 weeks post-surgery.
Main Results:
- New bone formation increased over time in the AdBMP-2 group, significantly exceeding the control group at 4 weeks.
- Maxillary sinus height was maintained in both groups.
- Confocal microscopy confirmed bMSC contribution to new bone formation in the control group.
Conclusions:
- AdBMP-2 gene-modified bMSCs effectively promote new bone formation in rabbit maxillary sinus elevation.
- The OsteoBone scaffold is a suitable carrier for gene-enhanced bone tissue engineering applications.
