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Oral midazolam in paediatric premedication

K A Payne1, A R Coetzee, F J Mattheyse

  • 1Department of Anaesthesiology, University of Stellenbosch, Parowvallei, CP.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|April 6, 1991
PubMed

Insights

Oral midazolam is an effective pediatric premedication, improving behavior and recovery time in children undergoing anesthesia. This study compared it against other regimens, finding superior results for oral midazolam.

Area of Science:

  • Anesthesiology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Premedication is crucial for managing pediatric anxiety and improving anesthetic induction.
  • Evaluating different premedication agents is essential for optimizing patient care.

Purpose of the Study:

  • To compare the efficacy of oral trimeprazine tartrate, methadone, droperidol (TMD), intramuscular midazolam, and oral midazolam as premedication in children.
  • To assess the impact of these regimens on behavior, cardiovascular stability, oxygen saturation, and recovery time.

Main Methods:

  • A study involving 135 children aged 1-10 years.
  • Four premedication regimens were administered 60 minutes before halothane anesthesia.
  • Behavioral assessments, oxygen saturation, and recovery times were recorded.

Main Results:

  • Oral and intramuscular midazolam significantly improved child behavior compared to placebo or TMD (P < 0.05).
  • Children under 5 years exhibited less satisfactory behavior than older children (P < 0.01).
  • Oral midazolam demonstrated a 70% faster recovery than the TMD regimen (P < 0.05).

Conclusions:

  • Oral midazolam is a more effective pediatric premedication agent than placebo or TMD.
  • Midazolam, administered orally or intramuscularly, enhances patient behavior during anesthesia induction.
  • Further research into optimal pediatric premedication strategies is warranted.

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