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Related Experiment Video

Updated: Jun 16, 2026

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

Age-related changes in niche cells influence hematopoietic stem cell function.

Erin J Oakley¹, Gary Van Zant

¹Department of Internal Medicine and Markey Cancer Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA.

|February 11, 2010

Summary

This summary is machine-generated.

Young blood signals can rejuvenate aging hematopoietic stem cells. This study shows that factors from young mice improve stem cell function in older mice through the niche environment.

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Published on: March 21, 2017

Area of Science:

Hematology
Stem Cell Biology
Aging Research

Background:

Hematopoietic stem cell (HSC) function declines with age.
The aging process affects the bone marrow microenvironment, impacting HSCs.
Systemic factors may play a role in age-related HSC dysfunction.

Purpose of the Study:

To investigate the effect of systemic signals from young animals on aged HSC function.
To determine if the microenvironmental niche mediates the rejuvenation of HSCs.
To elucidate the mechanisms underlying age-related HSC decline.

Main Methods:

Parabiosis surgery was performed, joining young and old mice.
Hematopoietic stem cell function was assessed in both young and old parabionts.
The bone marrow microenvironmental niche was analyzed in parabiotically joined mice.

Main Results:

Young parabionts showed enhanced HSC function compared to old parabionts.
Aged HSCs in young parabionts exhibited rejuvenated function.
Systemic factors from the young parabiont altered the aged HSC niche, leading to improved function.

Conclusions:

Systemic signals from young individuals can rejuvenate aged hematopoietic stem cells.
The microenvironmental niche is a critical mediator of age-related HSC changes.
Rejuvenation of HSC function is achievable through manipulation of systemic and niche factors.