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Related Experiment Videos

Excessive weight gain after liver transplantation.

M Palmer1, F Schaffner, S N Thung

  • 1Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, City University of New York, New York 10029.

Transplantation
|April 1, 1991
PubMed
Summary

Excessive weight gain is common after liver transplant, especially in the first 16 months. Pre-existing obesity predicts significant post-transplant weight gain, increasing risks for hepatic abnormalities.

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Metabolic Medicine

Background:

  • Orthotopic liver transplant (OLT) recipients often experience significant weight changes post-surgery.
  • Understanding weight gain patterns and predictors is crucial for managing post-transplant complications.

Purpose of the Study:

  • To determine the frequency of excessive weight gain after OLT.
  • To identify predictors of post-transplant weight gain in liver transplant recipients.

Main Methods:

  • Prospective evaluation of 28 OLT patients pre- and post-transplant.
  • Analysis of weight changes, body mass index (BMI), and clinical/laboratory parameters.
  • Comparison between overweight and non-overweight patient groups.

Main Results:

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  • 64.3% of patients gained weight post-OLT, with the majority becoming overweight.
  • Pre-transplant overweight status was a significant predictor of post-transplant weight gain (P < 0.005).
  • Overweight patients exhibited higher rates of weight gain and more comorbidities, including hypertension and abnormal liver tests.

Conclusions:

  • Excessive weight gain is a frequent and early complication following OLT.
  • Obesity prior to transplant is a key predictor, but all patients are at risk.
  • Post-transplant obesity can complicate the interpretation of hepatic test results and may contribute to liver abnormalities.