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Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy

Hiroaki Kitaoka1, Toru Kubo, Makoto Okawa

  • 1Department of Medicine and Geriatrics, Kochi Medical School.

International Heart Journal
|February 11, 2010
PubMed

Insights

Plasma adiponectin levels are linked to impaired left ventricular systolic function in hypertrophic cardiomyopathy (HCM) patients. Adiponectin, along with B-type natriuretic peptide (BNP), may serve as a biomarker for assessing HCM disease severity.

Area of Science:

  • Cardiology
  • Biochemistry
  • Biomarkers

Background:

  • Adiponectin, an adipose-derived protein, exhibits antiatherosclerogenic properties.
  • Elevated adiponectin levels are noted in heart failure patients.
  • The role of adiponectin in hypertrophic cardiomyopathy (HCM) remains unexplored.

Purpose of the Study:

  • To investigate the clinical significance of plasma adiponectin levels in patients diagnosed with HCM.
  • To determine the relationship between adiponectin levels and clinical/echocardiographic parameters in HCM.

Main Methods:

  • Evaluated clinical characteristics, echocardiographic parameters, and plasma levels of B-type natriuretic peptide (BNP) and adiponectin in 106 HCM patients.
  • Performed correlation analyses to identify relationships between adiponectin and various parameters.
  • Utilized multivariate analysis to identify independent predictors of plasma adiponectin levels.

Main Results:

  • Plasma adiponectin levels showed positive correlation with age and inverse correlation with body mass index (BMI).
  • Adiponectin levels were inversely related to % fractional shortening and maximum LV wall thickness.
  • A significant positive correlation was observed between plasma adiponectin and BNP levels.

Conclusions:

  • Plasma adiponectin levels are associated with impaired left ventricular systolic function in HCM patients.
  • Adiponectin levels do not correlate with the left ventricular outflow gradient in HCM.
  • Adiponectin, in conjunction with BNP, shows potential as a biomarker for assessing HCM disease severity.

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