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Positive pregnancy tests in a postmenopausal woman due to beta-human chorionic gonadotropin production by multiple
Nishant Tageja1, Jason Valent, Tamar Giorgadze
1Departments of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA. ntageja@med.wayne.edu
Abstract:
Extensive immunochemical characterization has shown that the free beta subunit of hCG (betahCG) can be produced by common epithelial tumors, including lung, colon, and bladder. However, the expression of beta-human chorionic gonadotropin (hCG) in hematologic malignancies and its significance is largely unknown. We present an extremely rare case of positive serum betahCG in a postmenopausal woman with relapsed, refractory multiple myeloma with myeloma cells expressing betahCG on immunohistochemical stain.
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