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In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
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Infectious vasculopathy of intracranial large- and medium-sized vessels in neurological intensive care unit: a

J Katchanov1, E Siebert, R Klingebiel

  • 1Department of Neurology, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany. juri.katchanov@charite.de

Neurocritical Care
|February 11, 2010
PubMed
Abstract

Insights

Infections cause a significant portion of nonatherosclerotic cerebral vasculopathy. Infectious vasculopathy often presents with abnormal imaging and cerebrospinal fluid findings, leading to poor patient outcomes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neuroradiology

Background:

  • Infections are a known cause of cerebral vasculopathy and vasculitis.
  • Understanding the role of infections in nonatherosclerotic central nervous system vasculopathy is crucial for diagnosis and management.

Purpose of the Study:

  • To analyze the frequency of intracranial vasculopathy attributed to infection.
  • To identify causative microorganisms, imaging, and cerebrospinal fluid (CSF) characteristics.
  • To evaluate the clinical course and outcomes of infectious vasculopathy.

Main Methods:

  • Retrospective review of patients diagnosed with nonatherosclerotic central nervous system vasculopathy (1999-2009).
  • Analysis of clinical charts, imaging data (including magnetic resonance angiography), and CSF studies.
  • Identification of causative pathogens and assessment of patient outcomes.

Main Results:

  • Eight of 25 adult patients (32%) had infectious vasculopathy affecting large and medium intracranial vessels.
  • Common causes included bacterial meningitis, varicella zoster virus (VZV), borreliosis, and syphilis.
  • Infectious vasculopathy cases showed abnormal imaging (100% MRA), elevated CSF white blood cell counts, and poor neurological outcomes (death, locked-in syndrome, severe deficits).

Conclusions:

  • Infectious vasculopathy accounts for one-third of nonatherosclerotic vasculopathy cases in this cohort.
  • Prompt diagnosis and treatment are essential due to the severe clinical course and unfavorable outcomes associated with infectious vasculopathy.

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