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Tumor-induced osteomalacia originating from the temporal bone: a case report
Kenya Kobayashi1, Kazunari Nakao, Kensuke Kawai
1Department of Otolaryngology, Head and Neck Surgery, Kanto Medical Center NTT EC, Tokyo, Japan. kenyajp@hotmail.com
Head & Neck
|February 11, 2010
Summary
Tumor-induced osteomalacia (TIO) is a rare disorder caused by tumors secreting FGF-23. Surgical tumor removal effectively cured a patient, normalizing phosphate levels and resolving symptoms.
Area of Science:
- Endocrinology
- Oncology
- Nephrology
Background:
- Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome.
- Characterized by hypophosphatemia due to excessive fibroblast growth factor 23 (FGF-23).
- Tumor resection is the definitive curative treatment.
Observation:
- A 53-year-old woman presented with prolonged bone pain and weakness.
- Diagnosed with TIO, exhibiting refractory hypophosphatemia and elevated FGF-23.
- A hypervascular temporal bone mass was identified via imaging.
Findings:
- Surgical resection of the temporal bone tumor was performed.
- Post-surgery, FGF-23 levels normalized, and phosphate reabsorption improved.
- All patient symptoms resolved after complete tumor removal.
Implications:
- Highlights the importance of identifying and resecting tumors in TIO management.
- Demonstrates successful treatment outcomes for TIO via surgical intervention.
- Emphasizes the role of FGF-23 in the pathogenesis of TIO.
