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Related Concept Videos

Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

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Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

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Staphylococcal Skin Infections

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Endocarditis II: Clinical Features of Infective Endocarditis

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Related Experiment Videos

[Necrotizing fasciitis].

Anders Peter Skovsen1, Jan Bonde, Jakob Steen Andersen

  • 1Rigshospitalet, Intensiv Terapiklinik, Afsnit 4131, Denmark. skovsen@dadlnet.dk

Ugeskrift for Laeger
|February 12, 2010
PubMed
Summary
This summary is machine-generated.

Necrotizing fasciitis (NF) is a severe infection requiring prompt treatment. A multidisciplinary protocolled approach significantly reduced mortality in intensive care unit patients, despite high rates of septic shock and organ failure.

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Surgical Infections

Background:

  • Necrotizing fasciitis (NF) is a rapidly progressing soft-tissue infection with high mortality and morbidity.
  • Early diagnosis and aggressive treatment are critical for improving patient outcomes.
  • This study investigates patient demographics, causative microorganisms, and treatment results for NF.

Purpose of the Study:

  • To determine the number of patients with necrotizing fasciitis admitted to the unit.
  • To identify the microorganisms responsible for NF infections.
  • To evaluate the treatment outcomes and mortality rates in NF patients.

Main Methods:

  • A retrospective cohort study of 85 patients admitted to a multidisciplinary, tertiary Intensive Care Unit between 2005 and 2007.
  • All patients received protocolled intensive care, surgical débridements, broad-spectrum antibiotics, intravenous immunoglobulin, and hyperbaric oxygen.
  • Data collected included microbiological findings, clinical status, and mortality.

Main Results:

  • Polymicrobial infections were found in 51% of cases, with beta-hemolytic streptococci being common in single-pathogen infections (74%).
  • High rates of critical illness were observed: 91% required mechanical ventilation, 67.5% had septic shock, and 25.3% developed acute renal failure.
  • Intensive care unit mortality was 6%, and 30-day mortality was 9.5%, significantly lower than the predicted mortality (38%).
  • Patients exhibited a higher body mass index compared to other unit admissions.

Conclusions:

  • Necrotizing fasciitis is a complex condition frequently leading to multi-organ failure.
  • A coordinated, protocolled treatment strategy involving intensive care, microbiology, and surgical specialties can substantially decrease mortality in high-risk NF patients.