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Updated: Jun 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Migraine and cardiovascular disease: a population-based study.

M E Bigal¹, T Kurth, N Santanello

¹1 Merck Dr., PO Box 100, Whitehouse Station, NJ 08889-0100, USA. marcelo_bigal@merck.com

|February 12, 2010

Summary

This summary is machine-generated.

Migraine, with or without aura, is linked to a higher risk of cardiovascular disease (CVD) and its risk factors. This large study confirms the association, though clinical significance requires further evaluation.

Related Experiment Videos

Last Updated: Jun 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Area of Science:

Cardiology
Neurology
Epidemiology

Background:

The association between migraine and cardiovascular disease (CVD) is recognized, but specific details regarding different migraine types and risk factors require further elucidation.
Understanding these links is crucial for comprehensive patient care and risk stratification.

Purpose of the Study:

To compare the prevalence of diagnosed CVD and CVD risk factors in individuals with migraine with aura (MA) and migraine without aura (MO) against a control group.
To assess the association between different types of migraine and cardiovascular outcomes.

Main Methods:

A case-control study involving 6,102 migraineurs and 5,243 controls, representative of the adult US population.
Migraine diagnosis was confirmed via a validated mailed questionnaire. CVD events were self-reported, and CVD risk factors were calculated, including modified Framingham scores.

Main Results:

Migraine, both MA and MO, was associated with increased risks of myocardial infarction, stroke, and claudication.
Migraineurs exhibited higher rates of diabetes, hypertension, and high cholesterol compared to controls, with risks elevated in MA and MO.
Adjusted analyses confirmed significant associations between migraine and myocardial infarction, stroke, and claudication.

Conclusions:

Both migraine with aura and migraine without aura are significantly associated with cardiovascular disease and its risk factors.
While the associations are statistically significant, the clinical relevance of these findings warrants further investigation due to the large sample size.