Related Experiment Video
Updated: Jun 16, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
Inflammation: planning for a source of pharmacokinetic/pharmacodynamic variability in translational studies
1Department of Clinical Pharmacology/Modeling and Simulation, GlaxoSmithKline, Research Triangle Park, North Carolina, USA. ginny.d.schmith@gsk.com
Abstract:
The impact of inflammation on variability in the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs should be considered in the design, analysis, and interpretation of clinical pharmacology studies. Data suggest that the metabolism and transport of drugs, as well as the expression of receptors, may change in the presence of inflammation. The clinical implications of these changes are not straightforward; they may vary depending on whether the inflammation is active or controlled and may change with time and successful treatment of the inflammation.
Related Concept Videos
Dosage Regimen: Individualization
Pharmacogenetics of Drug Metabolism: Overview
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Bioavailability Study Design: Healthy Subjects Versus Patients
Analysis of Population Pharmacokinetic Data
