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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...

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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

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An efficient protocol for NMR-spectroscopy-based structure determination of protein complexes in solution

Bernd Simon¹, Tobias Madl, Cameron D Mackereth

¹European Molecular Biology Laboratory, Heidelberg, Germany.

Angewandte Chemie (International Ed. in English)

|February 12, 2010

Summary

No abstract available in PubMed .

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