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Primary peritoneal spindle cell sarcoma presented with massive ascites: a case report.

A Bilici¹, K Uygun, E Altun

¹Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey. ahmetknower@yahoo.com

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology

|February 12, 2010

Summary

This case report details a rare primary peritoneal spindle cell sarcoma presenting with massive ascites. Chemotherapy with doxorubicin and ifosfamide led to symptom improvement and ascites regression.

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Ascites

Ascites

DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...

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Area of Science:

Oncology
Pathology

Background:

Soft tissue sarcomas (STSs) are rare neoplasms originating from mesenchymal cells.
Primary peritoneal sarcomas, including leiomyosarcoma, liposarcoma, and carcinosarcoma, have been documented.

Observation:

A 38-year-old woman presented with massive ascites.
The diagnosis was primary peritoneal spindle cell sarcoma, a type previously unreported.

Findings:

The patient received doxorubicin and ifosfamide chemotherapy.
Symptoms improved, and ascites regressed following treatment.

Implications:

Primary peritoneal spindle cell sarcoma is a rare but significant cause of massive ascites.
Consider primary peritoneal sarcomas in the differential diagnosis for malignancy-associated massive exudative ascites.

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