Layer-by-layer assembled polyampholyte microgel films for simultaneous release of anionic and cationic molecules

Area of Science:

• Materials Science
• Polymer Chemistry
• Nanotechnology

Background:

• Developing advanced matrix films for co-loading and simultaneous release of oppositely charged molecules is challenging.
• Layer-by-layer (LbL) assembly is a versatile technique for fabricating multilayered structures.

Purpose of the Study:

• To establish a facile LbL assembly method for fabricating matrix films capable of co-loading and simultaneous release of oppositely charged molecules.
• To utilize polyampholyte microgels as building blocks for these advanced matrix films.

Main Methods:

• Polyampholyte microgels (PAH-D-CO(2)) containing amine and carbamate groups were LbL assembled with poly(sodium 4-styrenesulfonate) (PSS).
• Fabrication was verified using quartz crystal microbalance and cross-sectional scanning electron microscopy.
• Anionic methyl orange and cationic rhodamine 6G were co-loaded and their release was studied.

Main Results:

• Successful fabrication of PAH-D-CO(2)/PSS multilayer films was confirmed.
• High loading capacity for both anionic and cationic dyes was achieved due to abundant functional groups and swelling capacity.
• Simultaneous release of methyl orange and rhodamine 6G was observed in normal saline.
• Release behavior could be tailored by adding barrier layers.

Conclusions:

• A facile LbL assembly method using polyampholyte microgels enables co-loading and simultaneous release of oppositely charged molecules.
• These polyampholyte microgel films demonstrate potential as matrixes for co-loading and controlled release of functional guest materials, including drugs.