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Updated: Jun 16, 2026
High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
Synthesis of a sensitive and selective potassium-sensing fluoroionophore
Richard D Carpenter1, A S Verkman
1Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, USA.
None:
An efficient synthesis is reported that delivers in 5 steps and 52% overall yield a new structurally simplified fluorescent K(+) sensor with improved K(+) sensitivity and selectivity over existing K(+) sensors. The synthesis procedure utilizes a new template-directed oxidative C-N bond-forming macrocyclization reaction and reports new approaches to Pd(0), Sandmeyer-like and metal-free aminoarylations, as well as organotitanium additions to vinylogous sulfonates.
