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Related Experiment Video

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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Human sex differences in d-amphetamine self-administration.

Andrea R Vansickel¹, William W Stoops, Craig R Rush

¹Department of Psychology, University of Kentucky, Lexington, KY, USA.

Addiction (Abingdon, England)

|February 13, 2010

Summary

This summary is machine-generated.

Sex differences in stimulant reinforcement were examined. Women found low-dose amphetamine reinforcing, while men preferred high doses, indicating distinct sensitivity to amphetamine's effects.

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Area of Science:

Neuroscience
Psychopharmacology
Behavioral Science

Background:

Stimulants like amphetamine and cocaine can elicit different responses in women and men.
Understanding sex-based differences in drug reinforcement is crucial for addiction research and treatment.

Purpose of the Study:

To assess potential sex differences in the reinforcing effects of d-amphetamine.
To analyze retrospective data from studies using similar d-amphetamine self-administration procedures.

Main Methods:

Retrospective analysis of data from 10 women and 15 men across three studies.
Participants self-administered placebo, low (8-10 mg), or high (16-20 mg) oral d-amphetamine doses.
Reinforcing effects were measured using a modified progressive-ratio schedule of reinforcement.

Main Results:

Low-dose d-amphetamine acted as a reinforcer in women, but not in men.
High-dose d-amphetamine acted as a reinforcer in men, but not in women.
Men self-administered significantly more capsules than women under the high-dose condition.

Conclusions:

Men exhibit greater sensitivity to the reinforcing effects of high-dose d-amphetamine compared to women.
Future research should prospectively investigate weight-adjusted d-amphetamine doses and control for menstrual cycle phase.