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Updated: Jun 16, 2026
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1
Ting Ting Chang1, Tzung Lieh Yeh, Nan Tsing Chiu
1Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.
Objectives:
Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.
Methods:
Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1.
Results:
Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT.
Conclusions:
Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.
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