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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

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Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

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Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
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Related Experiment Videos

Risk factors for gouty dactylitis.

R Andracco1, G Zampogna, M Parodi

  • 1Clinica Reumatologica, Dipartimento di Medicina Interna, Università di Genova, Italy.

Clinical and Experimental Rheumatology
|February 13, 2010
PubMed
Summary

Dactylitis in gout patients is linked to longer disease duration and more severe symptoms. Key predictors include renal stones, upper extremity involvement, and higher erythrocyte sedimentation rate (ESR).

Area of Science:

  • Rheumatology
  • Gout Research
  • Inflammatory Arthritis

Background:

  • Dactylitis, or 'sausage digit,' is a severe manifestation of gout.
  • Understanding its risk factors is crucial for managing gout progression.

Purpose of the Study:

  • To identify clinical and laboratory risk factors associated with dactylitis in gout patients.
  • To determine predictors of dactylitis in established gout.

Main Methods:

  • Retrospective review of 73 gout patients diagnosed by ACR criteria.
  • Screening for dactylitis and analysis of clinical and laboratory data.

Main Results:

  • Dactylitis was present in 9.6% of patients.
  • Risk factors included longer disease duration, more involved joints, higher serum uric acid, tophi, elevated ESR, and more ACR criteria.

Related Experiment Videos

  • Logistic regression identified renal stones, upper extremity involvement, number of ACR criteria, and ESR as significant predictors.

    • Conclusions:

    • Dactylitis is a significant feature of gout.
    • Its presence indicates more severe disease and is associated with specific clinical and laboratory findings.