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Updated: Jun 16, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Alterations in the spermatic function generated by obesity in rats.

Rosa María Vigueras-Villaseñor¹, Julio César Rojas-Castañeda, Margarita Chávez-Saldaña

¹Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, México D.F., México. marcoviv@servidor.unam.mx

Acta Histochemica

|February 13, 2010

Summary

Obesity negatively impacts sperm quality by affecting the epididymis, not the testes. High-fat diets in rats led to increased lipid peroxidation and morphological changes in the epididymis, impacting sperm parameters.

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White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

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Published on: September 9, 2025

Area of Science:

Reproductive Biology
Endocrinology
Toxicology

Background:

Obesity is a global health concern with potential adverse effects on male reproductive health.
Understanding the specific impact of obesity on testicular and epididymal function is crucial for reproductive medicine.

Purpose of the Study:

To investigate the effects of diet-induced obesity on epididymal and germinal epithelia in rats.
To evaluate morphological, hormonal, and biochemical changes associated with obesity in the male reproductive system.

Main Methods:

Comparison of obese rats (high-fat diet) and control rats.
Assessment of testicular and epididymal morphology.
Measurement of serum leptin, estradiol, testosterone, insulin, glucose, cholesterol, and triglycerides.
Analysis of epididymal lipid peroxidation and spermatobioscopic parameters.

Main Results:

Obese rats exhibited significantly increased serum leptin and estradiol levels, with decreased testosterone levels.
Increased lipid peroxidation was observed in the epididymis of obese rats.
Morphological differences were noted in the epididymis of obese rats, while testes showed no significant changes.
Spermatobioscopic parameters were reduced in obese rats.

Conclusions:

Diet-induced obesity adversely affects epididymal function and sperm quality in rats.
The epididymis appears to be a primary site of impact for obesity-related sperm damage, rather than the testes.