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SOCIC: the store-operated calcium influx complex.

Luis Vaca1

  • 1Departamento de Biología Celular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Del. Coyoacan, 04510 México, DF, Mexico. lvaca@ifc.unam.mx

Cell Calcium
|February 13, 2010
PubMed
Summary

Store-operated calcium influx (SOC) is activated by protein complex assembly, involving STIM1 and Orai, within specialized lipid raft domains. Novel components of the store-operated calcium influx complex (SOCIC) are being identified, highlighting lipids

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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Calcium signaling is crucial for cellular functions.
  • Store-operated calcium channels (SOCs) regulate calcium influx upon depletion of intracellular stores.
  • STIM1 and Orai proteins are key players in SOC activation.

Purpose of the Study:

  • To review the evidence for macromolecular complex assembly in SOC activation.
  • To highlight novel members of the store-operated calcium influx complex (SOCIC).
  • To discuss the role of lipid rafts in store-operated calcium entry (SOCE).

Main Methods:

  • Review of existing literature on calcium signaling and SOCE.
  • Analysis of studies identifying protein and lipid components of SOCIC.
  • Discussion of the spatial organization of SOCIC within lipid rafts.

Main Results:

  • SOC activation requires the assembly of macromolecular complexes, including STIM1 and Orai.
  • Novel SOCIC members like TRPC1, SERCA, and EB1 have been identified.
  • SOCIC assembly occurs in specialized lipid raft domains, suggesting lipid involvement in SOCE regulation.

Conclusions:

  • Macromolecular complex assembly is essential for SOC activation.
  • The SOCIC is a dynamic complex with newly identified protein and potentially lipid components.
  • Lipid rafts play a critical role in modulating store- and agonist-activated calcium influx.