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The yin and yang of B cells in graft rejection and tolerance

Valeriya Zarkhin1, Geetha Chalasani, Minnie M Sarwal

  • 1Department of Pediatrics, Stanford University, Stanford, CA, USA. msarwal@stanford.edu

Transplantation Reviews (Orlando, Fla.)
|February 13, 2010
PubMed

Various lineages of B cells are being increasingly recognized as important players in the etiology and prognosis of both acute and chronic graft rejection. The role of immature, chronically activated B cells, as efficient antigen-presenting cells, supporting recalcitrant cell-mediated graft rejection and late lineage B cells driving humoral rejections, is being increasingly recognized. This review captures the recent literature on this subject and discusses the various roles of the B cell in renal graft rejection and conversely, also in graft tolerance, both in animal and human studies. In addition, novel therapies targeting specific B-cell lineages in graft rejection are also discussed, with a view to developing more targeted therapies for graft rejection.

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