Related Experiment Video
Updated: Jun 16, 2026

Using SecM Arrest Sequence as a Tool to Isolate Ribosome Bound Polypeptides
Published on: June 19, 2012
Protein folding on the ribosome
Lisa D Cabrita1, Christopher M Dobson, John Christodoulou
1Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Abstract:
In living systems, polypeptide chains are synthesised on ribosomes, molecular machines composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from the ribosomal exit tunnel and into the cellular environment, the majority must fold into specific structures in order to function. In this article we discuss recent approaches designed to reveal how such folding occurs and review our current knowledge of this complex self-assembly process.
Related Concept Videos
Protein Folding
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding
Protein Folding
Molecular Chaperones and Protein Folding
The...
Molecular Chaperones and Protein Folding
The...
Proteins: From Genes to Degradation
Transcription is the synthesis of RNA molecules by RNA...

