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Updated: Jun 16, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and
Muthukumar Karuppasamy1, Manojkumar Mahapatra, Samiye Yabanoglu
1Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India.
Abstract:
3,5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 10(3)-10(5). The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (K(i)) values obtained by molecular docking studies were in congruence with their experimental (K(i)) values.
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