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Study of Pt/TiO2 nanocomposite for cancer-cell treatment
Lei Liu1, Peng Miao, Yuanyuan Xu
1Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
Abstract:
The increasing incidence of cancer all over the world demands new, effective and secure materials for treatment. In this paper, we propose Pt/TiO(2) nanocomposite for cancer-cell treatment because noble metal nanoparticles are supposed to enhance the photocatalytic activity of TiO(2) nanoparticles. To evaluate the cancer-cell killing effect of our Pt/TiO(2) nanocomposite, TiO(2) and Au/TiO(2) nanoparticles are also introduced. The prepared Pt/TiO(2) nanocomposite are characterized with transmission electron microscopy (TEM) and UV-vis adsorption spectra. Results of cell treatment indicate that Pt/TiO(2) nanocomposite, as extremely stable metal-semiconductor nanomaterial, can exhibit a very high photodynamic efficiency under a mild ultraviolet radiation. And our Pt/TiO(2) nanocomposite shows to be more effective in cancer-cell treatment than TiO(2) and Au/TiO(2) nanoparticles. As a result, Pt/TiO(2) nanocomposite may be supposed to have a promising application for cancer-cell treatment.
