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Related Experiment Videos

Barrier cells in the spleen.

L Weiss1

  • 1Laboratory of Experimental Hematology and Cell Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6046.

Immunology Today
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Newly identified barrier cells rapidly increase in the spleen during stress, enhancing blood clearance and immune responses. These versatile cells play a crucial role in the spleen

Area of Science:

  • Immunology
  • Cell Biology
  • Hematology

Background:

  • The spleen's primary function is blood clearance, which can be enhanced under stress.
  • Barrier cells are a recently identified type of activated fibroblastic cells in the splenic pulp.

Purpose of the Study:

  • To review the role of barrier cells in the spleen's response to stress.
  • To elucidate the functions of barrier cells in splenic physiology.

Main Methods:

  • This is a review article, synthesizing existing research on barrier cells.
  • Focuses on the cellular and functional aspects of barrier cells in the spleen.

Main Results:

  • Barrier cells significantly increase in number during splenic stress (e.g., infection, inflammation).

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  • They augment splenic filtration, regulate blood flow, and support immune and hematopoietic functions.
  • Barrier cells are crucial for the spleen's expanded capacities in clearance, phagocytosis, and immunological reactivity.

    • Conclusions:

    • Barrier cells are key players in the spleen's adaptive responses to various stressors.
    • Their functions extend beyond the spleen, suggesting broader roles in tissue repair and immune induction.