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Updated: Jun 16, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Methylation of the DCC gene is lost in advanced gastric cancer

Kenji Hibi1, Makiko Sakata, Kazuma Sakuraba

  • 1Department of Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan. kenjih-ngy@umin.ac.jp

Anticancer Research
|February 13, 2010
PubMed
Abstract

Insights

Aberrant methylation of the Deleted in colorectal carcinoma (DCC) gene occurs in gastric cancer. DCC gene methylation was detected in 44% of gastric tumors but decreased in advanced stages.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • The Deleted in colorectal carcinoma (DCC) gene, a Netrin-1 receptor, is part of the functional dependence receptor family.
  • Functional dependence receptors can induce apoptosis when their ligands are absent.
  • Previous studies found aberrant DCC gene methylation in 56% of colorectal carcinomas.

Purpose of the Study:

  • To investigate the methylation status of the DCC gene in gastric carcinoma.
  • To correlate DCC gene methylation with clinicopathological findings in gastric cancer patients.

Main Methods:

  • Quantitative methylation-specific polymerase chain reaction (qMSP) was used to analyze DCC gene methylation.
  • DCC methylation was assessed in 36 primary gastric carcinomas and matched normal tissues.
  • Clinicopathological data, including TNM stage, were correlated with methylation status.

Main Results:

  • Aberrant DCC gene methylation was detected in 44% (16/36) of primary gastric carcinomas.
  • DCC methylation showed a significant correlation with the TNM stage of gastric cancer (p=0.0093).

Conclusions:

  • DCC gene methylation is implicated in the process of gastric carcinogenesis.
  • DCC methylation appears to be lost during the progression to advanced gastric carcinoma.

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